Path ID: DB00201_MESH_D018781_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D002110 | caffeine | Drug |
| UniProt:P29274 | Adenosine receptor A2a | Protein |
| UniProt:P29275 | Adenosine receptor A2b | Protein |
| InterPro:IPR023088 | 3’5’-cyclic nucleotide phosphodiesterase | GeneFamily |
| GO:0004016 | adenylate cyclase activity | BiologicalProcess |
| GO:0006198 | cAMP catabolic process | BiologicalProcess |
| MESH:D000242 | Cyclic AMP | ChemicalSubstance |
| GO:0019233 | sensory perception of pain | BiologicalProcess |
| HP:0012531 | Pain | PhenotypicFeature |
| MESH:D018781 | Tension-Type Headache | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Caffeine | DECREASES ACTIVITY OF | Adenosine Receptor A2A |
| Caffeine | DECREASES ACTIVITY OF | Adenosine Receptor A2B |
| Caffeine | DECREASES ACTIVITY OF | 3’5’-Cyclic Nucleotide Phosphodiesterase |
| Adenosine Receptor A2A | POSITIVELY REGULATES | Adenylate Cyclase Activity |
| Adenosine Receptor A2B | POSITIVELY REGULATES | Adenylate Cyclase Activity |
| 3’5’-Cyclic Nucleotide Phosphodiesterase | POSITIVELY REGULATES | Camp Catabolic Process |
| Adenylate Cyclase Activity | INCREASES ABUNDANCE OF | Cyclic Amp |
| Camp Catabolic Process | DECREASES ABUNDANCE OF | Cyclic Amp |
| Cyclic Amp | POSITIVELY REGULATES | Sensory Perception Of Pain |
| Sensory Perception Of Pain | POSITIVELY CORRELATED WITH | Pain |
| Pain | CONTRIBUTES TO | Tension-Type Headache |
Reference:
- https://go.drugbank.com/drugs/DB00201#mechanism-of-action
- https://en.wikipedia.org/wiki/Caffeine
- https://en.wikipedia.org/wiki/Adenosine_receptor
- https://en.wikipedia.org/wiki/Cyclic_nucleotide_phosphodiesterase
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5366829/
- https://en.wikipedia.org/wiki/Tension_headache