Path ID: DB00194_MESH_D016849_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D014740 | vidarabine | Drug |
| MESH:D001084 | Vidarabine Phosphate | ChemicalSubstance |
| UniProt:P04293 | DNA polymerase catalytic subunit | Protein |
| GO:0039686 | bidirectional double-stranded viral DNA replication | BiologicalProcess |
| GO:0090503 | RNA phosphodiester bond hydrolysis, exonucleolytic | BiologicalProcess |
| GO:0043631 | RNA polyadenylation | BiologicalProcess |
| taxonomy:10299 | Human alphaherpesvirus 1 strain 17 | OrganismTaxon |
| MESH:D016849 | Keratitis, Herpetic | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Vidarabine | HAS METABOLITE | Vidarabine Phosphate |
| Vidarabine Phosphate | DECREASES ACTIVITY OF | Dna Polymerase Catalytic Subunit |
| Dna Polymerase Catalytic Subunit | POSITIVELY REGULATES | Bidirectional Double-Stranded Viral Dna Replication |
| Dna Polymerase Catalytic Subunit | POSITIVELY REGULATES | Rna Phosphodiester Bond Hydrolysis, Exonucleolytic |
| Dna Polymerase Catalytic Subunit | POSITIVELY REGULATES | Rna Polyadenylation |
| Rna Polyadenylation | IN TAXON | Human Alphaherpesvirus 1 Strain 17 |
| Bidirectional Double-Stranded Viral Dna Replication | IN TAXON | Human Alphaherpesvirus 1 Strain 17 |
| Rna Phosphodiester Bond Hydrolysis, Exonucleolytic | IN TAXON | Human Alphaherpesvirus 1 Strain 17 |
| Human Alphaherpesvirus 1 Strain 17 | CAUSES | Keratitis, Herpetic |
Comment: This disease is also known as Herpes simplex keratitis as per DrugCentral. The drug needs to be converted to Vidarabine Phosphate first (monophosphate –> diphosphate –> triphosphate) to become active and exert its role as inhibitor (https://pubchem.ncbi.nlm.nih.gov/compound/21704#section=Mechanism-of-Action).
Reference: