Path ID: DB00188_MESH_D009101_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D000069286 | Bortezomib | Drug |
| UniProt:P28074 | Proteasome subunit beta type-5 | Protein |
| UniProt:P20618 | Proteasome subunit beta type-1 | Protein |
| GO:0071159 | NF-kappaB complex | CellularComponent |
| GO:0043161 | Proteasome-mediated ubiquitin-dependent protein catabolic process | BiologicalProcess |
| GO:0006915 | Apoptotic process | BiologicalProcess |
| MESH:D009101 | Multiple myeloma | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Bortezomib | DECREASES ACTIVITY OF | Proteasome Subunit Beta Type-5 |
| Bortezomib | DECREASES ACTIVITY OF | Proteasome Subunit Beta Type-1 |
| Bortezomib | DECREASES ACTIVITY OF | Nf-Kappab Complex |
| Proteasome Subunit Beta Type-5 | PARTICIPATES IN | Proteasome-Mediated Ubiquitin-Dependent Protein Catabolic Process |
| Proteasome Subunit Beta Type-1 | PARTICIPATES IN | Proteasome-Mediated Ubiquitin-Dependent Protein Catabolic Process |
| Nf-Kappab Complex | NEGATIVELY REGULATES | Apoptotic Process |
| Proteasome-Mediated Ubiquitin-Dependent Protein Catabolic Process | NEGATIVELY REGULATES | Apoptotic Process |
| Apoptotic Process | NEGATIVELY CORRELATED WITH | Multiple Myeloma |
Reference: