Path ID: DB00187_MESH_D001281_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:C036604 | esmolol | Drug |
| UniProt:P08588 | Beta-1 adrenergic receptor | Protein |
| InterPro:IPR030672 | Adenylate cyclase | GeneFamily |
| CHEBI:17489 | 3’,5’-cyclic AMP | ChemicalSubstance |
| GO:0070509 | Calcium ion import | BiologicalProcess |
| GO:0086003 | Cardiac muscle cell contraction | BiologicalProcess |
| MESH:D001281 | Atrial fibrillation | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Esmolol | DECREASES ACTIVITY OF | Beta-1 Adrenergic Receptor |
| Beta-1 Adrenergic Receptor | INCREASES ACTIVITY OF | Adenylate Cyclase |
| Adenylate Cyclase | INCREASES ABUNDANCE OF | 3’,5’-Cyclic Amp |
| 3’,5’-Cyclic Amp | POSITIVELY REGULATES | Calcium Ion Import |
| Calcium Ion Import | POSITIVELY REGULATES | Cardiac Muscle Cell Contraction |
| Cardiac Muscle Cell Contraction | POSITIVELY CORRELATED WITH | Atrial Fibrillation |
Comment: Esmolol hydrochloride inhibits the beta1 receptors located chiefly in cardiac muscle, but this preferential effect is not absolute and at higher doses it begins to inhibit beta2 receptors located chiefly in the bronchial and vascular musculature.
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