Path ID: DB00186_MESH_D012640_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D008140 | Lorazepam | Drug |
| InterPro:IPR006028 | Gamma-aminobutyric acid A receptor/Glycine receptor alpha | GeneFamily |
| GO:0022851 | GABA-gated chloride ion channel activity | MolecularActivity |
| GO:0060081 | Membrane hyperpolarization | BiologicalProcess |
| GO:0019228 | Neuronal action potential | BiologicalProcess |
| GO:0050806 | Positive regulation of synaptic transmission | BiologicalProcess |
| MESH:D012640 | Atonic seizure | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Lorazepam | POSITIVELY REGULATES | Gamma-Aminobutyric Acid A Receptor/Glycine Receptor Alpha |
| Gamma-Aminobutyric Acid A Receptor/Glycine Receptor Alpha | POSITIVELY REGULATES | Gaba-Gated Chloride Ion Channel Activity |
| Gaba-Gated Chloride Ion Channel Activity | POSITIVELY CORRELATED WITH | Membrane Hyperpolarization |
| Membrane Hyperpolarization | NEGATIVELY REGULATES | Neuronal Action Potential |
| Neuronal Action Potential | CONTRIBUTES TO | Positive Regulation Of Synaptic Transmission |
| Positive Regulation Of Synaptic Transmission | POSITIVELY CORRELATED WITH | Atonic Seizure |
Reference: