Path ID: DB00186_MESH_D001007_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D008140 | Lorazepam | Drug |
| InterPro:IPR006028 | Gamma-aminobutyric acid A receptor/Glycine receptor alpha | GeneFamily |
| GO:0007214 | Gamma-aminobutyric acid signaling pathway | BiologicalProcess |
| HP:0100852 | Abnormal fear/anxiety-related behavior | PhenotypicFeature |
| MESH:D007319 | Sleeplessness | Disease |
| MESH:D001007 | Anxiety | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Lorazepam | INCREASES ACTIVITY OF | Gamma-Aminobutyric Acid A Receptor/Glycine Receptor Alpha |
| Gamma-Aminobutyric Acid A Receptor/Glycine Receptor Alpha | POSITIVELY REGULATES | Gamma-Aminobutyric Acid Signaling Pathway |
| Gamma-Aminobutyric Acid Signaling Pathway | NEGATIVELY REGULATES | Abnormal Fear/Anxiety-Related Behavior |
| Gamma-Aminobutyric Acid Signaling Pathway | NEGATIVELY REGULATES | Sleeplessness |
| Abnormal Fear/Anxiety-Related Behavior | POSITIVELY CORRELATED WITH | Anxiety |
| Sleeplessness | POSITIVELY CORRELATED WITH | Anxiety |
Reference: