Path ID: DB00153_MESH_D010024_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| DB:DB00153 | ergocalciferol | Drug |
| CHEBI:86320 | 1α,25-dihydroxyvitamin D2 | ChemicalSubstance |
| UniProt:P11473 | Vitamin D3 receptor | Protein |
| GO:0070561 | vitamin D receptor signaling pathway | BiologicalProcess |
| GO:0045453 | bone resorption | BiologicalProcess |
| GO:0035898 | parathyroid hormone secretion | BiologicalProcess |
| CL:0000092 | osteoclast | Cell |
| GO:0070509 | calcium ion import | BiologicalProcess |
| HP:0002901 | Hypocalcemia | PhenotypicFeature |
| MESH:D010024 | Osteoporosis | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Ergocalciferol | HAS METABOLITE | 1Α,25-Dihydroxyvitamin D2 |
| 1Α,25-Dihydroxyvitamin D2 | INCREASES ACTIVITY OF | Vitamin D3 Receptor |
| Vitamin D3 Receptor | POSITIVELY REGULATES | Vitamin D Receptor Signaling Pathway |
| Vitamin D Receptor Signaling Pathway | POSITIVELY REGULATES | Calcium Ion Import |
| Vitamin D Receptor Signaling Pathway | NEGATIVELY REGULATES | Parathyroid Hormone Secretion |
| Parathyroid Hormone Secretion | POSITIVELY REGULATES | Osteoclast |
| Osteoclast | POSITIVELY CORRELATED WITH | Bone Resorption |
| Bone Resorption | POSITIVELY CORRELATED WITH | Osteoporosis |
| Calcium Ion Import | NEGATIVELY CORRELATED WITH | Hypocalcemia |
| Hypocalcemia | POSITIVELY CORRELATED WITH | Osteoporosis |
Reference: