Path ID: DB00146_MESH_D012279_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D002112 | calcifediol | Drug |
| MESH:D002117 | calcitriol | ChemicalSubstance |
| UniProt:P11473 | Vitamin D3 receptor | Protein |
| GO:0004498 | calcidiol 1-monooxygenase activity | MolecularActivity |
| GO:0055074 | calcium ion homeostasis | BiologicalProcess |
| GO:0030282 | bone mineralization | BiologicalProcess |
| MESH:D012279 | Rickets | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Calcifediol | PRODUCES | Calcitriol |
| Calcitriol | INCREASES ACTIVITY OF | Vitamin D3 Receptor |
| Vitamin D3 Receptor | POSITIVELY REGULATES | Calcidiol 1-Monooxygenase Activity |
| Calcidiol 1-Monooxygenase Activity | POSITIVELY CORRELATED WITH | Calcium Ion Homeostasis |
| Calcium Ion Homeostasis | POSITIVELY CORRELATED WITH | Bone Mineralization |
| Bone Mineralization | NEGATIVELY CORRELATED WITH | Rickets |
Reference: