Path ID: DB00146_MESH_D012080_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D002112 | calcifediol | Drug |
| MESH:D002117 | calcitriol | ChemicalSubstance |
| UniProt:P11473 | Vitamin D3 receptor | Protein |
| GO:0004498 | calcidiol 1-monooxygenase activity | MolecularActivity |
| GO:0055074 | calcium ion homeostasis | BiologicalProcess |
| HP:0004363 | Abnormal circulating calcium concentration | PhenotypicFeature |
| HP:0002901 | Hypocalcemia | PhenotypicFeature |
| MESH:D012080 | Renal osteodystrophy | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Calcifediol | PRODUCES | Calcitriol |
| Calcitriol | INCREASES ACTIVITY OF | Vitamin D3 Receptor |
| Vitamin D3 Receptor | POSITIVELY REGULATES | Calcidiol 1-Monooxygenase Activity |
| Calcidiol 1-Monooxygenase Activity | POSITIVELY CORRELATED WITH | Calcium Ion Homeostasis |
| Calcium Ion Homeostasis | NEGATIVELY CORRELATED WITH | Abnormal Circulating Calcium Concentration |
| Abnormal Circulating Calcium Concentration | SUPERCLASS OF | Hypocalcemia |
| Hypocalcemia | MANIFESTATION OF | Renal Osteodystrophy |
Reference: