Path ID: DB00115_MESH_D014806_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| DB:DB00115 | cyanocobalamin | Drug |
| UniProt:Q99707 | methionine synthase | Protein |
| UniProt:P22033 | Methylmalonyl-CoA mutase, mitochondrial | Protein |
| GO:0046105 | thymidine biosynthetic process | BiologicalProcess |
| CHEBI:16625 | methylmalonyl-CoA | ChemicalSubstance |
| GO:0090592 | DNA synthesis involved in DNA replication | BiologicalProcess |
| HP:0002912 | Methylmalonic acidemia | PhenotypicFeature |
| GO:0051301 | cell division | BiologicalProcess |
| HP:0000707 | Abnormality of the nervous system | PhenotypicFeature |
| HP:0020060 | Decreased red blood cell count | PhenotypicFeature |
| MESH:D014806 | Cobalamin deficiency | Disease |
| HP:0001889 | Megaloblastic anemia | PhenotypicFeature |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Cyanocobalamin | POSITIVELY REGULATES | Methionine Synthase |
| Cyanocobalamin | POSITIVELY REGULATES | Methylmalonyl-Coa Mutase, Mitochondrial |
| Methionine Synthase | PARTICIPATES IN | Thymidine Biosynthetic Process |
| Methylmalonyl-Coa Mutase, Mitochondrial | NEGATIVELY REGULATES | Methylmalonyl-Coa |
| Thymidine Biosynthetic Process | PARTICIPATES IN | Dna Synthesis Involved In Dna Replication |
| Methylmalonyl-Coa | POSITIVELY CORRELATED WITH | Methylmalonic Acidemia |
| Dna Synthesis Involved In Dna Replication | PART OF | Cell Division |
| Methylmalonic Acidemia | CAUSES | Abnormality Of The Nervous System |
| Cell Division | NEGATIVELY CORRELATED WITH | Decreased Red Blood Cell Count |
| Abnormality Of The Nervous System | POSITIVELY CORRELATED WITH | Cobalamin Deficiency |
| Decreased Red Blood Cell Count | POSITIVELY CORRELATED WITH | Megaloblastic Anemia |
| Megaloblastic Anemia | POSITIVELY CORRELATED WITH | Cobalamin Deficiency |
Reference: