Path ID: DB00108_MESH_D009103_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D000069442 | Natalizumab | Drug |
| UniProt:P13612 | Integrin alpha-4 | Protein |
| GO:1904994 | regulation of leukocyte adhesion to vascular endothelial cell | BiologicalProcess |
| GO:0050900 | leukocyte migration | BiologicalProcess |
| GO:0006954 | inflammation | BiologicalProcess |
| MESH:D009103 | Multiple sclerosis | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Natalizumab | MOLECULARLY INTERACTS WITH | Integrin Alpha-4 |
| Integrin Alpha-4 | PARTICIPATES IN | Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell |
| Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell | REGULATES | Leukocyte Migration |
| Leukocyte Migration | REGULATES | Inflammation |
| Inflammation | CAUSES | Multiple Sclerosis |
Reference: