Path ID: DB00105_MESH_D007943_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:C554127 | interferon alfa-2b | Drug |
| UniProt:P48551 | Interferon alpha/beta receptor 2 | Protein |
| UniProt:P17181 | Interferon alpha/beta receptor 1 | Protein |
| GO:0042100 | B cell proliferation | BiologicalProcess |
| GO:0006915 | apoptotic process | BiologicalProcess |
| MESH:D015513 | Oncogene Proteins | Protein |
| MESH:D007943 | Hairy cell leukemia | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Interferon Alfa-2B | MOLECULARLY INTERACTS WITH | Interferon Alpha/Beta Receptor 2 |
| Interferon Alfa-2B | MOLECULARLY INTERACTS WITH | Interferon Alpha/Beta Receptor 1 |
| Interferon Alpha/Beta Receptor 2 | NEGATIVELY REGULATES | B Cell Proliferation |
| Interferon Alpha/Beta Receptor 1 | NEGATIVELY REGULATES | B Cell Proliferation |
| Interferon Alpha/Beta Receptor 2 | POSITIVELY REGULATES | Apoptotic Process |
| Interferon Alpha/Beta Receptor 1 | POSITIVELY REGULATES | Apoptotic Process |
| Interferon Alpha/Beta Receptor 2 | DECREASES ABUNDANCE OF | Oncogene Proteins |
| Apoptotic Process | NEGATIVELY CORRELATED WITH | Hairy Cell Leukemia |
| Interferon Alpha/Beta Receptor 1 | DECREASES ABUNDANCE OF | Oncogene Proteins |
| Oncogene Proteins | POSITIVELY CORRELATED WITH | Hairy Cell Leukemia |
| B Cell Proliferation | POSITIVELY CORRELATED WITH | Hairy Cell Leukemia |
Comment: The precise mechanisms of action of interferons have not been fully elucidated but appear to be complex, and the resultant activities appear to be substantially interrelated.
Reference: