Path ID: DB00105_MESH_C554498_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:C554127 | interferon alfa-2b | Drug |
| UniProt:P48551 | Interferon alpha/beta receptor 2 | Protein |
| UniProt:P17181 | Interferon alpha/beta receptor 1 | Protein |
| GO:0007259 | receptor signaling pathway via JAK-STAT | BiologicalProcess |
| reactome:R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | Pathway |
| taxonomy:37296 | Human gammaherpesvirus 8 | OrganismTaxon |
| MESH:C554498 | Kaposi’s sarcoma associated with AIDS | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Interferon Alfa-2B | MOLECULARLY INTERACTS WITH | Interferon Alpha/Beta Receptor 2 |
| Interferon Alfa-2B | MOLECULARLY INTERACTS WITH | Interferon Alpha/Beta Receptor 1 |
| Interferon Alpha/Beta Receptor 2 | POSITIVELY REGULATES | Receptor Signaling Pathway Via Jak-Stat |
| Interferon Alpha/Beta Receptor 1 | POSITIVELY REGULATES | Receptor Signaling Pathway Via Jak-Stat |
| Receptor Signaling Pathway Via Jak-Stat | POSITIVELY CORRELATED WITH | Antiviral Mechanism By Ifn-Stimulated Genes |
| Antiviral Mechanism By Ifn-Stimulated Genes | DISRUPTS | Human Gammaherpesvirus 8 |
| Human Gammaherpesvirus 8 | CAUSES | Kaposi’S Sarcoma Associated With Aids |
Reference: