Path ID: DB00091_MESH_D007638_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D016572 | ciclosporin | Drug |
| UniProt:P62937 | Peptidyl-prolyl cis-trans isomerase A | Protein |
| GO:0005955 | Calcineurin complex | CellularComponent |
| GO:0070884 | calcineurin-NFAT signaling cascade | BiologicalProcess |
| GO:0032623 | Interleukin-2 production | BiologicalProcess |
| GO:0006954 | Inflammatory response | BiologicalProcess |
| GO:0042098 | T cell proliferation | BiologicalProcess |
| GO:0042110 | T cell activation | BiologicalProcess |
| MESH:D007638 | Keratoconjunctivitis sicca | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Ciclosporin | DECREASES ACTIVITY OF | Peptidyl-Prolyl Cis-Trans Isomerase A |
| Peptidyl-Prolyl Cis-Trans Isomerase A | PARTICIPATES IN | Calcineurin Complex |
| Calcineurin Complex | POSITIVELY REGULATES | Calcineurin-Nfat Signaling Cascade |
| Calcineurin Complex | POSITIVELY REGULATES | Calcineurin-Nfat Signaling Cascade |
| Calcineurin-Nfat Signaling Cascade | POSITIVELY REGULATES | Interleukin-2 Production |
| Interleukin-2 Production | POSITIVELY REGULATES | T Cell Proliferation |
| Interleukin-2 Production | POSITIVELY REGULATES | T Cell Activation |
| T Cell Proliferation | POSITIVELY CORRELATED WITH | Inflammatory Response |
| T Cell Activation | POSITIVELY CORRELATED WITH | Inflammatory Response |
| Inflammatory Response | POSITIVELY CORRELATED WITH | Keratoconjunctivitis Sicca |
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