Path ID: DB00087_MESH_D020529_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:C096529 | alemtuzumab | Drug |
| UniProt:P31358 | CAMPATH-1 antigen | Protein |
| GO:0006959 | humoral immune response | BiologicalProcess |
| GO:0001788 | antibody-dependent cellular cytotoxicity | BiologicalProcess |
| GO:0008219 | Cell death | BiologicalProcess |
| CL:0001063 | tumor cell | Cell |
| MESH:D020529 | Relapsing remitting multiple sclerosis | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Alemtuzumab | MOLECULARLY INTERACTS WITH | Campath-1 Antigen |
| Campath-1 Antigen | POSITIVELY REGULATES | Humoral Immune Response |
| Humoral Immune Response | POSITIVELY REGULATES | Antibody-Dependent Cellular Cytotoxicity |
| Antibody-Dependent Cellular Cytotoxicity | PRECEDES | Cell Death |
| Cell Death | DECREASES ABUNDANCE OF | Tumor Cell |
| Tumor Cell | MANIFESTATION OF | Relapsing Remitting Multiple Sclerosis |
Comment: NCIT:C38439 = mature lymphocytes could replace both B and T cell. Would have been an ideal node for this pair but could not be validated.
Reference: