Path ID: DB00026_MESH_D001172_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D053590 | Anakinra | Drug |
| UniProt:P14778 | Interleukin-1 receptor type 1 | Protein |
| GO:0004908 | Interleukin-1 receptor activity | MolecularActivity |
| reactome:R-HSA-1592389 | Activation of Matrix Metalloproteinases | Pathway |
| HP:0100773 | Cartilage destruction | PhenotypicFeature |
| MESH:D001172 | Rheumatoid arthritis | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Anakinra | DECREASES ACTIVITY OF | Interleukin-1 Receptor Type 1 |
| Interleukin-1 Receptor Type 1 | PARTICIPATES IN | Interleukin-1 Receptor Activity |
| Interleukin-1 Receptor Activity | POSITIVELY REGULATES | Activation Of Matrix Metalloproteinases |
| Activation Of Matrix Metalloproteinases | POSITIVELY REGULATES | Cartilage Destruction |
| Cartilage Destruction | OCCURS IN | Rheumatoid Arthritis |
Reference: