Path ID: DB00002_MESH_D003110_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D000068818 | cetuximab | Drug |
| UniProt:P00533 | Epidermal growth factor receptor | Protein |
| GO:0004697 | protein kinase C activity | MolecularActivity |
| GO:0050673 | epithelial cell proliferation | BiologicalProcess |
| GO:0006915 | apoptotic process | BiologicalProcess |
| MESH:D003110 | Malignant tumor of colon | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Cetuximab | DECREASES ACTIVITY OF | Epidermal Growth Factor Receptor |
| Epidermal Growth Factor Receptor | POSITIVELY REGULATES | Protein Kinase C Activity |
| Protein Kinase C Activity | POSITIVELY REGULATES | Epithelial Cell Proliferation |
| Protein Kinase C Activity | NEGATIVELY REGULATES | Apoptotic Process |
| Apoptotic Process | NEGATIVELY CORRELATED WITH | Malignant Tumor Of Colon |
| Epithelial Cell Proliferation | POSITIVELY CORRELATED WITH | Malignant Tumor Of Colon |
Reference: